Atrosan Liquid
50 mL
$ 17.79
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A.Vogel Atrosan Liquid
Used in herbal medicine to help relieve joint pain associated with osteoarthritis.
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More Info
Composition
Each 2.5 ml (½ tsp) contains:
Medicinal ingredient:
Devil’s Claw (Harpagophytum procumbens) secondary root tuber tincture (1:10) equivalent to 227.5 mg dried root
Non-medicinal ingredient:
1 mL of tincture contains 0.65 mL alcohol (ethanol).
1 mL = 33 drops. Dropper included.
Medicinal ingredient:
Devil’s Claw (Harpagophytum procumbens) secondary root tuber tincture (1:10) equivalent to 227.5 mg dried root
Non-medicinal ingredient:
1 mL of tincture contains 0.65 mL alcohol (ethanol).
1 mL = 33 drops. Dropper included.
Dosage
Adults: Take 2.5 mL (1/2 teaspoon), 3 times daily, with water, 15 minutes before meals. Salivate before swallowing.
Duration of use: Use for a minimum of 2-3 months to benefit from the product’s efficacy.
Duration of use: Use for a minimum of 2-3 months to benefit from the product’s efficacy.
Historical overview
Devils Claw gets its name from the "hooks" that cover the fruits skin, allowing the species to spread. Traditional African and European medicines use devils claw for its anti-inflammatory and analgesic properties as well as its tonic activity on the liver and stomach. Traditionally, it is used for arthritis, gout, muscle pain of all types (myalgia), lumbago, etc. as well as for loss of appetite, liver disorders and dyspepsia. In African pharmacopoeia, devils claw is used for urinary and menstrual problems.
Actions and pharmacology
Devils Claw active principles are iridoids in the form of glycosides (harpagoside, harpagide, procumbine) or aglycone (harpagegine), as well as flavonoids (kaempferol, apigenine). The anti-inflammatory activity of Devils Claw and its active components are controversial. A study published in 1992 evaluated the effect of devils claw on the production of eicosanoids (inflammation vectors, just like prostaglandin) during coagulation.(1) The results failed to prove the expected effect (that of non-steroidal anti-inflammatory agents) on the metabolism of arachidonic acid.
However, a more recent study evaluating the production of these eicosanoids found a very clear anti-inflammatory effect. It has been demonstrated that Devils Claw extract (particularly harpagosides) inhibits the synthesis of tromboxanes and leukotrienes.(2)
It seems that devils claw extract also has cardiac effects, which could limit its use in patients on heart medications. This effect has only been demonstrated in vitro and its actual relevance in humans has never been demonstrated.(3) Some authors also mention an hypoglycemic effect but no clinical data supports this affirmation.
The German Commission E acknowledges its benefits in cases of: loss of appetite, dyspepsia, supportive therapy of degenerative disorders of the locomotor system.
However, a more recent study evaluating the production of these eicosanoids found a very clear anti-inflammatory effect. It has been demonstrated that Devils Claw extract (particularly harpagosides) inhibits the synthesis of tromboxanes and leukotrienes.(2)
It seems that devils claw extract also has cardiac effects, which could limit its use in patients on heart medications. This effect has only been demonstrated in vitro and its actual relevance in humans has never been demonstrated.(3) Some authors also mention an hypoglycemic effect but no clinical data supports this affirmation.
The German Commission E acknowledges its benefits in cases of: loss of appetite, dyspepsia, supportive therapy of degenerative disorders of the locomotor system.
Scientific studies
Several well-designed clinical studies demonstrated the efficacy of Devils Claw in inflammatory disorders. A French double-blind randomized study compared a devils claw preparation and an anti-inflammatory agent (diacerhein) in 122 patients with hip and knee osteoarthritis over a period of 4 months. The Devils Claw extract proved as effective as the anti-inflammatory agent but had a much better tolerance and was safer.(4) A German 4-week study conducted on 197 patients with chronic back pain demonstrated that Devils Claw extract relieves and reduces irritation. Only a few minor and transient gastro-intestinal side effects were reported.(5)
Precautions, contraindications and interactions
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding.
Consult a healthcare practitioner if symptoms persist or worsen.
Avoid taking in case of known allergy to any of the ingredients in the product.
Do not use if security cap is broken. Keep out of reach of children.
Consult a healthcare practitioner if symptoms persist or worsen.
Avoid taking in case of known allergy to any of the ingredients in the product.
Do not use if security cap is broken. Keep out of reach of children.
References
1-Moussard C, Alber D, Toubin MM et al. A drug used in traditional medicine, Harpagophytum procumbens: no evidence for NSAID-like effect on whole blood eicosanoid production in humans. Prostaglandins Leukot Essential Fatty Acids 1992 Aug;46(4):283-6
2-Loew D, Mollerfeld J, Schrodter A et al. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin Pharmacol Ther 2001 May;69(5):356-64
3-Occhiuto F et al. A drug used in traditional medicine : Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. J Ethnopharmacol 1985;13:201-8.
4-Chantre P, Cappelaere A, Leblan D et al. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in the treatment of osteoarthritis. Phytomedicine 2000 Jun;7(3):177-83
5-Chrubasik S, Junck H, Breitschwerdt H et al. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anaesthesiol 1999 Feb;16(2):118-29
6-Shaw D, et al. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Safety 1997;17:342-56.
7-The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines. Blumenthal M et al. 1998. American Botanical Council, 6200 Manor Rd, Austin, Texas, 78723
2-Loew D, Mollerfeld J, Schrodter A et al. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin Pharmacol Ther 2001 May;69(5):356-64
3-Occhiuto F et al. A drug used in traditional medicine : Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. J Ethnopharmacol 1985;13:201-8.
4-Chantre P, Cappelaere A, Leblan D et al. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in the treatment of osteoarthritis. Phytomedicine 2000 Jun;7(3):177-83
5-Chrubasik S, Junck H, Breitschwerdt H et al. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anaesthesiol 1999 Feb;16(2):118-29
6-Shaw D, et al. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Safety 1997;17:342-56.
7-The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines. Blumenthal M et al. 1998. American Botanical Council, 6200 Manor Rd, Austin, Texas, 78723
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