A.Vogel Menopause
Menopause symptoms:
Hot Flashes - Night Sweats

Improves menopause symptoms such as hot flashes, nightly sweats and excessive sweating.

100% Organic Sage
		Reduces the frequency and severity of hot flashes and sweats.
		Promotes a good night’s rest!
		Clinically tested.
		Natural, safe and effective.
		Gluten- and lactose-free

More Info

Composition

Each tablet contains tincture of:
Medicinal ingredient:
Fresh Sage* (Salvia officinalis) leaf (1:17)…..3400 mg,
equivalent to 200 mg dried leaf.
Non-medicinal ingredients:
Microcrystalline cellulose, sucrose laurate, hydrogenated cottonseed oil.
* Certified organically grown by Bio Suisse

Dosage

Adults: Take one tablet once daily with water.

Historical overview

Sage (Salvia officinalis) is a shrub native of the Mediterranean basin. In ancient times, sage was traditionally considered a panacea (cure-all). As time went by some indications became more popular. In topical applications, sage is useful for inflammation of mucous membranes and tonsils. Orally, it helps to reduce excessive perspiration like that caused by severe malady (tuberculosis), it aids digestion and improves wound healing. For a long time, sages reputation as brain tonic was laughed at but, recently, its beneficial effect in Alzheimers disease was shown.(1)

Actions and pharmacology

Sage leaf contains tannins, bitter principles (diterpenes), steroids, flavonoids and a volatile oil rich in terpenes (thujone, camphor, etc.). It is recognized for its carminative (relieving flatulence), antispasmodic, anti-inflammatory, astringent, and anti-microbial properties. The antispasmodic and astringent effects may explain its usefulness against excessive perspiration and hot flushes.(2) In a recent in vitro study, sage has shown an affinity to benzodiazepine brain receptors which could explain its calming effect.(3) In another in vitro study, sage demonstrated antioxidant properties.(4)
The German E Commission recognizes the use of sage (Salvia Officinalis) for dyspeptic symptoms (poor digestion without apparent stomach lesion) and excessive perspiration.

Scientific studies

A multi-centre clinical trial assessed the tolerability and efficacy of Menopause tablets in menopausal women experiencing hot flashes.(5) This 8-week clinical trial investigated the safety and efficacy of a holistically standardized fresh herb sage extract, in a once-daily dosage in women aged between 50 and 65 who had been menopausal for at least 6 months and were experiencing at least 5 hot flashes daily.
Results:

After 4 weeks the average number of hot flashes had gone down by 50%
After 8 weeks the average number of hot flashes had gone down by 64%
The number of flashes was still decreasing during week 8, indicating that further reductions were most likely with continued treatment

The more intense the hot flashes, the better the results:

Mild flashes were reduced by 46%
Moderate flashes were reduced by 62%
Severe flashes were reduced by 79%
Very severe flashes were reduced by 100%

In the patient diaries, the average highest number of mild hot flashes at week 0 was 59 per day. This is more than one hot flash every half hour around the clock! After 8 weeks of therapy, the average highest number of mild hot flashes was 7.6 per day. Tolerability was rated as very good or good by 87.3% of the physicians as well as by 87.3% of the patients.

Precautions, contraindications and interactions

Avoid during pregnancy and nursing unless otherwise prescribed by your healthcare practitioner.
Avoid taking in case of known allergy to any of the ingredients in the product.
People suffering from epilepsy should refrain from taking large amounts of sage.
No interaction has been reported.
Do not use if safety seal is broken. Keep out of reach of children.

References

1- Akhondzadeh S, Noroozian M, Mohammadi M et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003 Feb;28(1):53-9.

2- Hoffmann D. The Herbalist CD-Rom. Hopkins Technology 1995. Minnesota USA

3- Kavvadias D, Monschein V, Sand P et al. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med 2003 Feb;69(2):113-7.

4- Hohmann J, Zupko I, Redei D et al. Protective effects of the aerial parts of Salvia officinalis, Melissa Officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med 1999 Aug;65(6):576-8.

5- Bommer S, Klein P, Suter A. A multicentre open clinical trial to assess the tolerability and efficacy of Sage tablets in climacteric women with hot flashes. 57th GA congress, Geneva, 2009. Poster