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Clinical Trial - Respiratory tract infections (RTI's)

Newly developed Echinacea formulation (Echinaforce Hot Drink) had similar efficacy to Oseltamivir, but with less risk of treatment complications.


Research showed a newly developed Echinacea formulation (Echinaforce Hot Drink) had similar efficacy to Oseltamivir, but with less risk of treatment complications.

Study: randomised, controlled, multicenter clinical trial

A randomised, controlled, multicenter clinical trial followed 473 people with influenza over 10 days, comparing the outcomes of treatment of the two medicines; Echinaforce® Hot Drink (over 10 days) or Oseltamivir (over 5 days followed by 5 days placebo). Nasal secretions were collected at first visit to help define the period of highest influenzal activity.

Recovery from influenza


Incidence of complications

The incidence of complications was also measured. In the Oseltamivir group, pneumonia, sinusitis, bronchitis and other complications occurred at a rate of 6.5% compared to 2.5% in the Echinaforce® Hot Drink group. Regarding gastrointestinal adverse events Echinaforce Hot Drink was favoured with 5 times fewer reports on vomiting, nausea and diarrhea.

Occurrence of complications



In this study, Echinaforce® Hot Drink was shown to be as effective as the neuraminidase inhibitor Oseltamivir, the gold standard for treatment and prevention of influenza. The clinical efficacy of Echinaforce® was seen in those diagnosed clinically with influenza, during peaks of influenza infection, as well as in those with virologically confirmed infections. Echinaforce® Hot Drink outperformed Oseltamivir in measures of risk of complications and safety. 

Dr. Peter Fisher, Royal London Hospital for Integrated Medicine, said: “Neuraminidase inhibitors such as Oseltamivir are the current ‘gold standard’ for flu treatment, but they have significant limitations and side effects. Despite different modes of action, we found Echinaforce Hot Drink to be as effective as the chemical gold standard but with a better safety profile.”

Echinaforce Hot Drink is readily available over-the-counter in pharmacies and health food shops. Since early treatment improves the outcome of flu this makes it a very attractive treatment option.

Dr. Andy Suter (Head of Medical Department, A. Vogel Bioforce AG, Switzerland): 
“We’re delighted that the new research not only shows the herb’s efficacy in typical cold and flus but the role it plays in favourable illness progression and consequent reduction of secondary complications. We also see that treatment effects vary greatly between different Echinacea products and cautious manufacturing of fresh plant material seems to be key. 3”

Raus K, Schoop R, Pleschka S, Klein P, Fisher P. Echinaforce Hotdrink versus Oseltamivir in influenza: A randomized, double-blind, double-dummy, multicenter, non-inferiority clinical trial. Curr Ther Res. 2015; accepted for publication.

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Have you found what you read useful? If so, I would love if you would leave your comment below. Thanks Sonia Chartier

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